SPM Active® Supplement

Targeted support for minor pain relief*
A few years ago my knees were sore and I had hard time walking. SPM has been a life saver. Knees get sore periodically, but more manageable.
Dianne
Supplement Facts
Serving size: 2 Softgels
Servings Per Container:

Specialized pro-resolving mediators (SPMs) help promote resolution of physical stress after strenuous physical exertion. SPM Active® supports the body’s natural capacity to respond to physical challenges.*

  • The only SPM supplement with human clinical data with demonstrated results*
  • Helps promote tissue health
  • Clinically demonstrated improvement in joint comfort, sleep, and mood†*

Study of 149 subjects who consumed an SPM product identical to SPM Active® (2 softgels) for 1 month and 120 subjects who consumed the SPM product for 3 months (2 softgels for one month and 1 softgel for the following two months).

 

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A few years ago my knees were sore and I had hard time walking. SPM has been a life saver. Knees get sore periodically, but more manageable.
Dianne
Supplement Facts
Serving size: 2 Softgels
Servings Per Container:
Benefits of SPM Active

Specialized pro-resolving mediators (SPMs) are molecules our bodies produce naturally in response to damaged tissue due to physical challenges and are a critical component of the body’s natural healing process. Unfortunately, the body may not produce enough SPMs on its own. Diet, lifestyle, excess body fat, and other health challenges can affect SPM production. That’s where our clinically studied SPM Active can help.*

SPMs have been known to support individuals experiencing:
Physical discomfort from everyday activities
Physical discomfort from everyday activities*
Exercise-related discomfort
Exercise-related
discomfort*
Reduced SPM production linked to excess body fat
Reduced SPM production linked to excess body fat*

To address the immune response, we first need to define it.

The human body is equipped with a natural defense called the immune system, which is designed to fight off external threats and damaged tissue caused by these threats and help the body return to homeostasis. Although the immune response is a natural process, it can be harmful to the body if left unresolved.

Defining the immune response
Immune response initiation
INITIATION

In a perfect world, the immune response should resolve itself.

The immune response ideally occurs in two phases: initiation and resolution. When a person experiences a physical challenge, lipid mediators and various other compounds are produced naturally in the body. This is called initiation and is marked by physical discomfort and other physical responses.1

RESOLUTION

But SPM production may be lacking.

During resolution, pro-resolving lipid mediators are produced and help the body to heal and repair itself naturally. Unfortunately, inadequate SPM production can hinder the body’s natural recovery process—leaving the immune response incomplete and unresolved.2

SPM production may be lacking
Role of specialized pro-resolving mediators
ROLE OF SPECIALIZED PRO-SOLVING MEDIATORS

That’s where SPM Active can help.

While scientists traditionally believed that resolution was a passive process, groundbreaking research has shown that resolution is an active process that’s dependent on adequate SPM status.3*

Initiation to resolution
SPMs initiation to resolution infographic

Why choose SPM Active?

We were the first.

Through collaboration and research with top-level scientists, we were the first to introduce SPMs to the market in 2015.

We've done our homework.

Over four years, we’ve demonstrated activity of our SPM Active formula and conducted six clinical interventions to discover the potential for SPMs to positively impact human health.

We expand the boundaries of nutritional science

Metagenics invested in the first intervention study with SPM standardized dietary supplement.5

The role of SPMs in the body

Reprogram immune cells
Reprogram immune cells

SPMs encourage immune cells to be more protective and less likely to amplify the negative effects of an environmental stressor.*

Help restore balance
Help restore balance

SPMs are necessary to return to homeostasis after a physical challenge and support overall wellbeing.*

Support resilience
Support resilience

SPM resolution activities play a role in the body’s ability to bounce back from environmental challenges.*

Resources

Clinical Summary

Clinical Summary

Download
SPM Active Formula Focus Sheet

Formula Focus Sheet

Download
The SPM Difference

The SPM Difference

Download

References

1. Serhan CN. Mol Aspects Med. 2017;58:1-11.
2. Serhan CN. FASEB J. 2017;31(4):1273-1288.
3. Dalli J et al. Br J Pharmacol. 2019;176(8):1024-1037.
4. Serhan CN. Nature. 2014;510(7503):92-101.
5. Souza PR et al. Circ Res. 2020;126(1):75-90.

 

Label & Supplement Facts

Average Customer Rating: (39 Reviews) This item can be reviewed only by verified buyers

These reviews have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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SPM Active

A viewer from Williamsburg, Michigan

I think you have wonderful products. My doctor recommended them. I like the multi vitamin. Thanks (Promotional Review)

Did you find this review useful? yes no  Certified buyer


Feel Better

A viewer from East Coast, USA

The product is easy to take, helps to reduce joint pain and inflammation. (Promotional Review)

Did you find this review useful? yes no  Certified buyer


SPM active is amazing

A viewer from Galt, Ca

I first heard about SPM active from my chiropractor. I was being treated for lower back issues. I was at a point where I was going to have back surgery. I began taking SPM active. After 3 weeks of taking SPM active my lower back pain decreased significantly. I’m going to continue to take SPM active and I am signed up for automatic shipment. This product is amazing. (Promotional Review)

Did you find this review useful? yes no  Certified buyer


SPM Active

A viewer from Walnut Creek, CA

Product helps with everyday aches and pains (Promotional Review)

Did you find this review useful? yes no  Certified buyer


SPM Active

A viewer from Gso nc

Has helped me tremendously (Promotional Review)

Did you find this review useful? yes no  Certified buyer