SPM Active® Supplement

Targeted support for minor pain relief*
A few years ago my knees were sore and I had hard time walking. SPM has been a life saver. Knees get sore periodically, but more manageable.
Supplement Facts
Serving size: 2 Softgels
Servings Per Container:

Specialized pro-resolving mediators (SPMs) help promote resolution of physical stress after strenuous physical exertion. SPM Active® supports the body’s natural capacity to respond to physical challenges.*

  • The only SPM supplement with human clinical data with demonstrated results*
  • Helps promote tissue health
  • Clinically demonstrated improvement in joint comfort, sleep, and mood†*

Study of 149 subjects who consumed an SPM product identical to SPM Active® (2 softgels) for 1 month and 120 subjects who consumed the SPM product for 3 months (2 softgels for one month and 1 softgel for the following two months).


View Full Product Details
Serving size, 2 Softgels.
Select Size Description
Subscribe & Save
    1 Time-purchase
  • $73.50
    1 Unit Free shipping over $100
    1 +
    Out of stock!
Free Shipping on Subscriptions. Cancel Anytime.
A few years ago my knees were sore and I had hard time walking. SPM has been a life saver. Knees get sore periodically, but more manageable.
Supplement Facts
Serving size: 2 Softgels
Servings Per Container:
Benefits of SPM Active

Specialized pro-resolving mediators (SPMs) are molecules our bodies produce naturally in response to damaged tissue due to physical challenges and are a critical component of the body’s natural healing process. Unfortunately, the body may not produce enough SPMs on its own. Diet, lifestyle, excess body fat, and other health challenges can affect SPM production. That’s where our clinically studied SPM Active can help.*

SPMs have been known to support individuals experiencing:
Physical discomfort from everyday activities
Physical discomfort from everyday activities*
Exercise-related discomfort
Reduced SPM production linked to excess body fat
Reduced SPM production linked to excess body fat*

To address the immune response, we first need to define it.

The human body is equipped with a natural defense called the immune system, which is designed to fight off external threats and damaged tissue caused by these threats and help the body return to homeostasis. Although the immune response is a natural process, it can be harmful to the body if left unresolved.

Defining the immune response
Immune response initiation

In a perfect world, the immune response should resolve itself.

The immune response ideally occurs in two phases: initiation and resolution. When a person experiences a physical challenge, lipid mediators and various other compounds are produced naturally in the body. This is called initiation and is marked by physical discomfort and other physical responses.1


But SPM production may be lacking.

During resolution, pro-resolving lipid mediators are produced and help the body to heal and repair itself naturally. Unfortunately, inadequate SPM production can hinder the body’s natural recovery process—leaving the immune response incomplete and unresolved.2

SPM production may be lacking
Role of specialized pro-resolving mediators

That’s where SPM Active can help.

While scientists traditionally believed that resolution was a passive process, groundbreaking research has shown that resolution is an active process that’s dependent on adequate SPM status.3*

Initiation to resolution
SPMs initiation to resolution infographic

Why choose SPM Active?

We were the first.

Through collaboration and research with top-level scientists, we were the first to introduce SPMs to the market in 2015.

We've done our homework.

Over four years, we’ve demonstrated activity of our SPM Active formula and conducted six clinical interventions to discover the potential for SPMs to positively impact human health.

We expand the boundaries of nutritional science

Metagenics invested in the first intervention study with SPM standardized dietary supplement.5

The role of SPMs in the body

Reprogram immune cells
Reprogram immune cells

SPMs encourage immune cells to be more protective and less likely to amplify the negative effects of an environmental stressor.*

Help restore balance
Help restore balance

SPMs are necessary to return to homeostasis after a physical challenge and support overall wellbeing.*

Support resilience
Support resilience

SPM resolution activities play a role in the body’s ability to bounce back from environmental challenges.*


Clinical Summary

Clinical Summary

SPM Active Formula Focus Sheet

Formula Focus Sheet

The SPM Difference

The SPM Difference



1. Serhan CN. Mol Aspects Med. 2017;58:1-11.
2. Serhan CN. FASEB J. 2017;31(4):1273-1288.
3. Dalli J et al. Br J Pharmacol. 2019;176(8):1024-1037.
4. Serhan CN. Nature. 2014;510(7503):92-101.
5. Souza PR et al. Circ Res. 2020;126(1):75-90.


Label & Supplement Facts

Average Customer Rating: (39 Reviews) This item can be reviewed only by verified buyers

These reviews have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sort by:

Great Product

Dianne from Jackson County Michigan

A few years ago my knees were so sore I was having a hard time walking. I was so blessed to find a chiropractor that recommended your SPM product. It has been a life saver for me. Knees get sore from time to time, but much more manageable. Thank you for such a great product and the great service.

3 of 3 people found this review helpful. Do you? yes no  Certified buyer

Spm active

Mariclaire Maldonado from California

I love all the products I use from metagenics.

0 of 1 people found this review helpful. Do you? yes no  Certified buyer

SPM Active

Diane Mondini from Newport Beach, CA

My doctor, Kelly McCann MD, in Newport Beach recommended this product several years ago. I have taken it ever since. I think it is far superior to regular fish oil capsules.

1 of 1 people found this review helpful. Do you? yes no  Certified buyer


Nancy Lasko from Ambridge Pa

This is a product i don't want to be without! I have it on auto ship! 3 days without it & I'm miserable . I am way less body achey & have more energy & more focused! LOVE IT!

Did you find this review useful? yes no  Certified buyer

Worth the price

A viewer from Limestone, TN

For the longest time I was struggling with pain in my ankles, knees, shoulders... most of my joints. My doctor recommended SPM Active. It greatly reduced the inflammation and pain in my joints, and I could feel a difference within a couple of days of starting this supplement. It is not the cheapest joint supplement, but it works better than anything I have tried. I've now been using this for the past 3 years, and count it as a permanent part of my health regimen. Also, by signing up for the auto-shipment, you get the supplement at a discounted price and it ensures you do not run out. Their subscriptions are very easy to manage, they email several days before they prepare to ship each time allowing you to change the date, pause the subscription, whatever you need. Very happy with this product! (Promotional Review)

Did you find this review useful? yes no  Certified buyer

Next Page